Publications:
Hamashin, C., Spindler, L., Russell, S., Schink, A., Lambkin, I., O'Mahony, D., Houghten, R., Pinilla, C. Identification of Novel Small-Molecule Ulex Europaeus I Mimetics for Targeted Drug Delivery. Bioorganic and Medicinal Chemistry (in press, 2003)
Lambkin, I., Pinilla, C., Hamashin, C., Spindler, L., Russell, S., Schink, A., Moya-Castro, R., Allicotti, G., Higgins, L., Smith, M., Dee, J., Wilson, C., Houghten, R., O'Mahony, D. Toward targeted oral vaccine delivery systems: Selection of lectin mimetics from combinatorial libraries. Pharmaceutical Research 20: 1258-1266, 2003.
Boggiano, C., Reixach, N., Pinilla, C., Blondelle, S.E. Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays. Biopolymers (Pept. Sci.) 71:103-116, 2003.
Pinilla, C., Appel, J.R., Borras, E., Houghten, R.A. Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. Nat. Med. 9:118-122, 2003.
Borras, E., Martin, R., Judkowski, V., Shukaliak, J., Zhao, Y., Rubio-Godoy, V., Valmori, D., Wilson, D., Simon, R., Houghten, R., Pinilla, C. Findings on T cell specificity revealed by synthetic combinatorial libraries. J. Immunol. Methods 267:79-97, 2002.
Dutoit, V., Rubio-Godoy, V., Pittet, M.J., Zippelius, A., Dietrich, P.Y., Legal, F.A., Guillaume, P., Romero, P., Cerottini, J.C., Houghten, R.A., Pinilla, C., Valmori, D. Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer+ CD8+ T cells in humans. J. Exp. Med. 196:207-216, 2002.
Houghten, R., Giulianotti, M., Pinilla, C. How to screen trillions of compounds. SP2 June 2002 36-37.
Houghten, R., Giulianotti, M., Pinilla, C. Mixed libraries speed up HTS further. SP2 August 2002 18-19.
Lambkin, I., Pinilla, C. Targeting approaches to oral drug delivery. Expert Opin. Biol. Ther. 2:67-73, 2002.
Rubio-Godoy, V., Ayyoub, M., Dutoit, V., Servis, C., Schink, A., Rimoldi, D., Romero, P., Cerottini, J.-C., Simon, R., Zhao, Y., Houghten, R.A., Pinilla, C., Valmori, D. Combinatorial peptide library based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity. Eur. J. Immunol. 32: 2292-2299, 2002.
Rubio-Godoy, V., Dutoit, V., Zhao, Y., Simon, R., Guillaume, P., Houghten, R.A., Romero, P., Cerottini, J.C., Pinilla, C., Valmori, D. Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide coss-reactivity with tumor-reactive Melan-A-specific CTL. J. Immunol. 169:5696-5707, 2002.
Rubio-Godoy, V., Pinilla, C., Dutoit, V., Borras, E., Simon, R., Zhao, Y., Cerottini, J.-C., Romero, P., Houghten, R.A., Valmori, D. Toward synthetic combinatorial peptide libraries in positional scanning format PS-SCL based identification of CD8+ tumor reactive T cell ligands: a comparative analysis of PS-SCL recognition by a single tumor-reactive CD8+ CTL clone. Cancer Research, 62:2058-2063, 2002.
La Rosa, C., Krishnan, R., Markel, S., Schneck, J.P., Houghten, R.A., Pinilla, C., Diamond, D.J. Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries. Blood 97:1776-1786, 2001.
Pinilla, C., Rubio-Godoy, V., Dutoit, V., Guillaume, P., Simon, R., Zhao, Y., Houghten, R., Cerottini, J., Romero, P., Valmori, D. Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor reactive cytolytic T. lymphocytes. Cancer Research, 61:5153-5160, 2001.
Zhao, Y., Gran, B., Pinilla, C., Markovic-Plese, S., Hemmer, B., Tzou, A., Whitney, L.W., Biddison, W.E., Martin, R., Simon, R. Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic T-cell receptors and MHC-peptide ligands. J. Immunol. 167:2130-2141, 2001.
Hemmer, B., Kondo, T., Gran, B., Pinilla, C., Cortese, I., Pascal, J., Tzou, A., McFarland, H.F., Houghten, R.A., Martin, R. Minimal peptide length requirements for CD4 T cell clones-implications for molecular mimicry and T cell survival. Int. Immunol. 12:375-383, 2000.
Hemmer, B., Pinilla, C., Gran, B., Vergelli, M., Ling, N., Conlon, P., McFarland, H.F., Houghten, R.A., Martin, R. Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency. J. Immunol. 164:861-871, 2000.
Houghten, R.A., Wilson, D.B., Pinilla, C. Drug and vaccine discovery using mixture-based synthetic combinatorial libraries. Drug Discovery Today 5:276-285, 2000.
Pinilla, C., Houghten, R.A., Wilson, D.B., Martin, R. Identification and optimization of antigens for T cell clones of clinical relevance using positional scanning combinatorial libraries. In: Peptides for the New Millenium, Proceedings of the 16th American Peptide Symposium (Fields, G.B., Tam, J.P., Barany, G., Eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 683-684, 2000.
Hemmer, B., Gran, B., Zhao, Y., Marques, A., Pascal, J., Tzou, A., Kondo, T., Cortese, I., Bielekova, B., Straus, S., McFarland, H.F., Houghten, R.A., Simon, R., Pinilla, C., Martin, R. Identification of candidate T cell epitopes and molecular mimics in chronic Lyme disease. Nature Medicine 5:1375-1382, 1999.
