Press Releases:

Feb. 14, 2002 - Mixture Sciences, Inc. of San Diego, California, entered a research collaboration with HeptaHelix Ltd. of Lund, Sweden, to use Mixture Sciences mixture-based combinatorial libraries to identify ligands for HeptaHelix collection of G-protein coupled receptors using their sensitive reporter analysis, a kind of biosensor system. Mixture Sciences will provide a variety of mutually selected mixture-based combinatorial libraries. Mixture Sciences and HeptaHelix will use these libraries to identify ligands for a variety of mutually selected cell-based reporter-gene systems including G-protein coupled and orphan receptors.

Mixture Sciences, Inc., www.mixturesciences.com, a privately-held biotechnology company, specializes in biomedical research and drug discovery. We use a combination of proprietary and in-licensed technologies for the discovery of therapeutic and diagnostic candidates for the treatment of HIV/AIDS, cancer, diabetes, multiple sclerosis, and infectious diseases, including Lyme Disease. Our technologies have been validated and used by members of the academic and corporate community over the past decade.

Our success comes from being a worldwide leader in the use of mixture-based chemical libraries. Our unique position allows us to provide our collaborators exceptional technologies and expertise. Mixture Sciences, Inc. is committed to developing, improving, patenting and in-licensing new technologies in order to provide our collaborators with the most cost efficient methods for identifying ligands.

HeptaHelix, www.gs-development.com, is a biotechnological company involved in researching the body's most important communication system, heptahelix receptors, using highly sensitive biosensors (reporter cells) to "fish out" candidate drugs acting on these receptors.

For various organs and tissues to function together requires that they can communicate with one another all the time. This is done by cells sending out chemical signals that can be understood by receptors on the surface of other cells. The most important family of these is the heptahelix receptors. They consist of long-chain molecules that 'sew' themselves in and out of the cell membrane seven (hepta) times, hence the name.